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Electricity Can Manipulate Human Genes

The frontier of wearable technology has taken a groundbreaking leap forward, according to recent research conducted at ETH Zurich. Wearable gadgets today can measure various vital signs, such as heart rate and blood pressure, aiding in health monitoring. However, these devices have been limited to passive observation without the ability to actively influence our metabolism or manage illnesses. That might be about to change.

In a paper published in the journal Nature Metabolism, the researchers unveiled an exciting new concept that demonstrates the possibility of harnessing electricity to influence human DNA directly. The study marks a significant shift in the potential applications of wearable technology, opening doors to gene-based therapies.


The researchers wrote, “Wearable electronic devices are playing a rapidly expanding role in the acquisition of individuals’ health data for personalized medical interventions. However, wearables cannot yet directly programme gene-based therapies because of the lack of a direct electrogenetic interface. Here we provide the missing link.”


The implications of this technology are profound. For instance, in the case of a person with diabetes, this technique could be used to boost insulin production in the body, directly addressing the ailment.


During the study, human pancreatic cells were implanted into mice with type 1 diabetes. These cells were then stimulated using direct current through acupuncture needles, a technology referred to as DART (DC-Actuated Regulation Technology).


The researchers believe that DART bridges the gap between the digital technology of gadgets and the analog technology of our bodies. The applied electricity generates non-toxic levels of reactive oxygen species, energetic molecules that can initiate a process leading to the activation of engineered cells responding to chemical changes.

In essence, this research indicates the possibility of manipulating how DNA inside the cell is regulated by altering their epigenetic ‘on/off switch.’ This ability to influence genetic factors could be transformative in treating various conditions affected by genetics.


While it might be premature to imagine a future where a simple wearable like a Fitbit band could transform our lives by effecting changes at the genetic level, this experiment represents a promising first step in that direction. The research lays the groundwork for a new era of personalized medical interventions, taking wearable technology beyond mere observation to active participation in managing and even curing illnesses. The age of electrogenetic interfaces may be closer than we think, signaling a bold new phase in the intersection of technology, biology, and health.






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